UpToDate

UpToDate is the world's gold-standard clinical decision support resource, published by Wolters Kluwer and trusted by over 2 million medical professionals across 10,000+ hospitals in more than 190 countries. Founded in 1992 by Dr. Burton Rose at Brigham and Women's Hospital, UpToDate pioneered the concept of continuously updated, expert-authored clinical reference content — and has remained the definitive point-of-care clinical tool for over 30 years, winning Best in KLAS for Clinical Decision Support four times between 2021 and 2025.

UpToDate's content spans 13,000+ clinical topics across 25 specialties, 10,000+ graded recommendations with transparent evidence levels, and 39,000+ graphics including algorithms, diagnostic flowcharts, and interactive decision tools — all written and continuously reviewed by physician experts rather than AI alone. Its integration with Lexicomp provides comprehensive drug information and interaction checking. CME/CE/CPD credits are earned during clinical research, accepted by dozens of accrediting organizations globally. In 2026, Wolters Kluwer launched UpToDate Expert AI — a generative AI conversational layer built on top of UpToDate's rigorously vetted content base, enabling clinicians to ask clinical questions in natural language and receive evidence-based answers grounded in expert-authored content rather than general internet data.

UpToDate is the right choice for clinicians, hospitals, and health systems that need the most comprehensive, authoritative, and continuously updated clinical reference available — particularly those who value depth of expert editorial review, transparent evidence grading, and the new Expert AI conversational interface as a complement to structured topic-based guidance.

UpToDate individual subscriptions start from $579/year for the core plan covering all clinical topics, drug information, CME/CE credits, and mobile access. UpToDate Pro Plus, which adds Expert AI and advanced medication decision support, is priced higher — exact pricing is displayed in the Wolters Kluwer online store at checkout after selecting country and profession.

Group plans for 2-19 clinicians offer discounted per-user rates available through the online store. Institutional licensing for hospitals and health systems is priced on request with dedicated implementation support, EHR integration, usage analytics, and enterprise management features.

Contact Wolters Kluwer through wolterskluwer.com/uptodate for institutional, group, and enterprise pricing.